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Some personal notes on ACE inhibitors
 I'm sticking this in opinion because I'm writing it as I go along and it only seems appropriate.
I already linked one article today yesterday on the subject of the interaction of the virus with ACE inhibitor receptors, that was something I happened to run across this morning. Based on some stuff from yesterday, I decided it would help a little to recap some of the more important links regarding both fraudulent materials and other notes on the subject:
- Slashdot: Retracted Covid Paper Lives on in New Citations. Way back in Spring 2020, the Surgisphere Corporation generated a huge amount of patient data out of whole cloth that purported to show that ACE inhibitors produced a negative outcome in Covid patients. It was published in the NEJM and then retracted when the fraud was discovered. Since then, it has been quoted a large number of times, and only about 1/6 of the papers referencing it have noted that it was fraudulent and retracted. See Med Page Today and the online cardiology news site tctmd for more information on this particular folllowup study.
- In the meantime, other studies have shown that ACE inhibitors were actually helpful, even as their use among hospitalized covid patients was discontinued:
- In the British Medical Journal: "Risk of severe COVID-19 disease with ACE inhibitors and angiotensin receptor blockers: cohort study including 8.3 million people" showed:
Abstract Findings: "Findings Of 19 486 patients who had COVID-19
disease, 1286 received ICU care. ACE inhibitors were associated
with a significantly reduced risk of COVID-19 disease (adjusted
HR 0.71, 95% CI 0.67 to 0.74) but no increased risk of ICU care
(adjusted HR 0.89, 95% CI 0.75 to 1.06) after adjusting for a
wide range of confounders. Adjusted HRs for ARBs were 0.63 (95%
CI 0.59 to 0.67) for COVID-19 disease and 1.02 (95% CI 0.83 to 1.25) for ICU care...
...Interpretation ACE inhibitors and ARBs are associated with reduced risks of COVID-19 disease after adjusting for a wide range of variables. Neither ACE inhibitors nor ARBs are associated with significantly increased risks of receiving ICU care. Variations between different ethnic groups raise the possibility of ethnic-specific effects of ACE inhibitors/ARBs on COVID-19 disease susceptibility and severity which deserves further study.
In other words, we adopted a practice of taking patients off of a drug they were taking already that was helpful in combatting Covid as a matter of standardized hospital protocol for the first year and a half of the epidemic because of a fraudulent paper.
And no-one with the nation's so-called intelligence agencies performed any sort of followup investigation into the fake science that convinced us to shoot our pandemic response in the foot. I guess it was just the hobby of the owner of Surgisphere?
Posted by: Thing From Snowy Mountain 2022-01-13
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