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Science & Technology |
ORF8 Corona Mutation Explained |
2020-11-03 |
August 25, 2020, but it helped me understand ORF8. Published in The Lancet (via Medical Express), the study details a coronavirus strain identified as ∆382 that doctors in Singapore studied between January and March, comparing it with other available SARS-CoV-2 strains that were circulating at the time. The researchers explain that the ∆382 mutation involves the deletion of 382 nucleotides that appears in the open reading frame 8 region (ORF8), which is a known spot for mutations in coronaviruses. As a result, the ORF8 protein is not produced, the researchers said. During the SARS epidemic nearly 20 years ago, a deletion of 29 nucleotides in the ORF8 region resulted in a variant of the virus that was unable to replicate as efficiently as the wild-type SARS virus. ![]() The researchers note that the ∆382 groups also showed a better immune response to the virus, including more effective platelet regulation and T cell responses early in the infection. The patients also showed a more robust production of a cytokine called IFN-γ, which could explain the heightened immune response. Interestingly, the observations held true even when taking age groups and comorbidities into account. The researchers think this version of the virus triggers a reduced pro-inflammatory response and a less-damaging cytokine storm, which results in a milder COVID-19 case. The researchers speculate that the absence of the ORF8 protein inhibits the virus’s ability to evade the immune system, but more research is needed to demonstrate these findings. More research; there must be more research! Even if the ∆382 mutation does cause a less severe version of COVID-19, there's no telling what one's chances are of getting infected with that milder strain instead of a more lethal version. But if the ORF8 hypothesis is correct and drugs can target the protein, doctors may be able to develop new therapies that can reduce COVID-19 complications. |
Posted by:Bobby |
#5 NN2N1, thanks for the statistics. Some of us did take statistics in college; and it's refreshing to see just a little bit of perspective and facts among all the hysteria. |
Posted by: Tom 2020-11-03 08:26 |
#4 It's easy to forget that Chinese made goods are shoddy. Is it any surprise the virus is holding up poorly? |
Posted by: M. Murcek 2020-11-03 07:40 |
#3 94% with an underlying medical issues of the population of those with enough symptoms to get tested? |
Posted by: Bright Pebbles 2020-11-03 07:35 |
#2 I have been posting the declining Infection to Death figures for several months. An also speaking of the multiple mutations of the C-19 since it hit the USA. Overall stated, the infection to Death Ratio has PEAKED back on April 18th, 2020. Despite the media telling us the last few weeks, .."...the C-19 infections are growing each week". The CDC own data shows Infection to DEATHS continue to decline. Figures are for the 7 days proceeding the indicated close date. DATE ............ CLAIMED C-19 DEATHS 10/10/2020......3,778 10/17/2020......3,300 10/24/2020......1,780 Preliminary figures for the 7 day period of 10/31/2020 are 166 as the CDC waits several days for States to officially report deaths. FOR THE LAST 7 DAYS The CDC main Covid-19 website reports the following as of 11-03-2020 @ 0445hrs: 77,398 New Cases and 451 New Deaths. Which works out to 0.5827023954107341 of 1% Infection to Deaths YEAR TO DATE INFECTION TO DEATH Totals To be infected you must be 1 of the 2.6849% to have gotten Infected and reported, and as we are told part of the 94% with an underlying medical issues. All in order to become 1 of the 2.5089% that died from the C-19. |
Posted by: NN2N1 2020-11-03 05:04 |
#1 >here's no telling what one's chances are of getting infected with that milder strain instead of a more lethal version. So get people infected with a known mild one... It's quicker, cheaper and here now (and probably safer than waiting for a unknown risk vaccine). |
Posted by: Bright Pebbles 2020-11-03 03:32 |