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| Science & Technology |
| The J&J conundrum |
| 2021-09-14 |
| h/t HotAir But many J.&J. recipients are less interested in receiving a second J.&J. shot than a follow-up shot with either the Moderna or Pfizer vaccine. They know that J.&J. seems less effective than other vaccines, and some J.&J. recipients have been frightened by reports of a very rare but serious blood clot. Notably, numerous doctors and some prominent experts who themselves received the J.&J. vaccine have chosen to receive a follow-up Moderna or Pfizer vaccine. The list includes Bill Enright, a biotechnology C.E.O.; Zoë McLaren, a health economist; and Angela Rasmussen, a prominent virologist. The city of San Francisco also began offering a Moderna or Pfizer booster shot to J.&J. recipients about a month ago... During a podcast interview this summer, Dr. Rochelle Walensky, the director of the C.D.C., declined to discourage J.&J. recipients from seeking out a Moderna or Pfizer shot. She said there was not enough data to be sure about the benefits and risks. But when Andy Slavitt, the podcast host and a former Biden adviser, asked her whether she would describe it as a "huge mistake," Walensky replied, "Not with what I’ve seen so far." From the head of a notoriously cautious agency, that was a remarkable and telling statement. mRNA vaccines are, probably, the safest (and most effective - due to gradual release of antigen) vaccines ever produced. |
| Posted by:g(r)omgoru |
| #13 g(r)you are, in my opinion, a advocate for the pharmaceuticals. I will remember this. |
| Posted by: rammer 2021-09-14 21:08 |
| #12 The mrna in the J&J vaccine is natural and would be destroyed in extracellular spaces by your body's enzymes. |
| Posted by: rammer 2021-09-14 20:39 |
| #11 no, g(r) the mrna in the vaccines is a synthetic uricil. Your body has a dozen enzymes to degrade mrna in your extracellular spaces. These mrna vaccines deliberately change the uricil to be indestructible in your body. It makes the same protein, but it doesn't degrade like your body would otherwise destroy it. We have evolved to destroy extracellular mrna. That was for a reason, and highly conserved. |
| Posted by: rammer 2021-09-14 20:28 |
| #10 So grom, having had covid and then 5 months later the J&J vaccine, what is the procedure? Start over with Pfizer series, take Pfizer booster, (is there a J&J booster?), I don't know. |
| Posted by: Glenmore 2021-09-14 14:12 |
| #9 rammer, rammer, rammer. J&J has an "artificial" virus containing Covid spike protein's mRNA. mRNA vaccines do the same thing via lipid vesicle (with proteins that mediate non-destructive entry of these vesicles into cells). Now, just think - if it was different RNA, then it would result in different protein = different immune response. Think of it as delivering the same type of cargo by train or by truck. |
| Posted by: g(r)omgoru 2021-09-14 11:49 |
| #8 ^Here you are wart 35 Years of Research Into Coronavirus Infections Show Long-Term Immunity Is Unlikely |
| Posted by: g(r)omgoru 2021-09-14 11:40 |
| #7 g(R) it is not the same mrna. J&J uses a weakened virus to deliver the antigen. The others use a synthetic uricil which doesn't get cut apart by the normal enzymes that degrade natural mrna. |
| Posted by: rammer 2021-09-14 10:57 |
| #6 ^ prove it |
| Posted by: Warthog 2021-09-14 09:53 |
| #5 ^Jeez MM, you take booster 6 months after the initial - by that time there isn't even a memory of the original shot left (that's why you need a booster) |
| Posted by: g(r)omgoru 2021-09-14 09:29 |
| #4 I like how incredibly complex interactions that have not even been studied in vivo yet can be dismissed as "no worries." See - Castle Bravo test. |
| Posted by: M. Murcek 2021-09-14 09:26 |
| #3 ...and the same RNA - they just get different ways to get it into the system. |
| Posted by: g(r)omgoru 2021-09-14 09:22 |
| #2 It's the same antigen end product, MM |
| Posted by: g(r)omgoru 2021-09-14 09:20 |
| #1 I have had no issues with the J&J vaccine. I'd be more concerned about mix n match problems. But that's just me. |
| Posted by: M. Murcek 2021-09-14 07:45 |