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Science & Technology
Trial suggests metformin effective at reducing odds of serious outcomes for COVID-19 patients seeking early treatment
2022-08-20
[Med Press] In work published in the New England Journal of Medicine, researchers—led by the University of Minnesota Medical School and School of Public Health—have found that metformin, a commonly prescribed diabetes medication lowers the odds of emergency department visits, hospitalizations, or death due to COVID-19 by over 40 percent—and over 50 percent if prescribed early in onset of symptoms.
That explains why we did not see the expected massive die-off of diabetics in the recent Covid situation.
The study also found no positive effect from treatment with either ivermectin or low-dose fluvoxamine.

"We are pleased to contribute to the body of knowledge around COVID-19 therapies in general, with treatments that are widely available," said Carolyn Bramante, MD, principal investigator of the study and an assistant professor of internal medicine and pediatrics at the U of M Medical School. "Our trial suggests that metformin may reduce the likelihood of needing to go to the emergency room or be hospitalized for COVID-19."

Bramante noted that this was a secondary outcome of the trial; the primary outcome included whether someone had low oxygen on a home oxygen monitor, and none of the medications in the trial prevented the primary outcome.

The COVID-OUT trial was the nation's first to study whether metformin, a medication for type 2 diabetes; low-dose fluvoxamine, an antidepressant; and ivermectin, an antiparasitic, or their combinations could serve as possible treatments to prevent ER visits or hospitalization, as well as Long-COVID.

The study design was simple—patients were randomly assigned to receive one of the three drugs individually, placebo, or a combination of metformin and fluvoxamine or metformin and ivermectin. Although the study was placebo-controlled with exact-matching placebo pills, Dr. Bramante says 83% of volunteers received medications supported by existing data because of the six-arm design. Each participant received 2 types of pills to keep their treatment assignment masked, for 3 to 14 days of treatment. Each volunteer tracked their symptoms, and after 14 days, they completed a survey.
Related:
Metformin: 2009-10-02 Scientists find path to fountain of youth
Related:
Fluvoxamine: 2021-12-17 Studies Proving Generic Drugs Can Fight COVID Are Being Suppressed
Related:
Ivermectin: 2022-07-15 Court: Air Force Cannot Discharge Troops Who Filed for Religious Exemptions from Vaccine Mandate
Ivermectin: 2022-07-01 NH Gov. Sununu signs pair of bills related to vaccine mandates, vetoes ivermectin legislation
Ivermectin: 2022-02-24 Football club bans players who have taken the coronary vaccine
Posted by:Besoeker

#6  This is not the trial I'm interested in.
Posted by: swksvolFF   2022-08-20 10:50  

#5  Biden admin said yesterday that the government will stop paying for covid test and treatments. So it would be about time for them to start pushing generic drugs.
Posted by: Chris   2022-08-20 10:28  

#4  I take it twice daily. For diabetes.
Posted by: Deacon Blues   2022-08-20 10:25  

#3  Great. Now metformin will be silently made illegal.
Posted by: Angstrom   2022-08-20 09:52  

#2  I smell bull shit here big time. Like the Univ. of Minnesota doesn't get one thin dime in grants from the feds. But, hmmm, I thought diabetics were at high risk. Then there's this gem which Tony Science couldn't have said better himself: "Although we know COVID-19 vaccines are highly effective...."
Posted by: DooDahMan   2022-08-20 09:35  

#1  Metformin is an inexpensive generic drug.

And therefore will be pilloried by our elites (and media).
Posted by: Mullah Richard   2022-08-20 08:09  

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