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| Science & Technology |
| Ancient 'pharaoh's curse' fungus shows promise in killing cancer cells |
| 2025-06-30 |
| [FoxNews] A potentially deadly fungus known as "pharaoh's curse fungus" could offer an unexpected path to fighting cancer, recent research shows. Scientists from the University of Pennsylvania modified molecules from the fungus — which is officially called Aspergillus flavus — to create a new compound and enhance its cancer-killing properties. "Fungi gave us penicillin," said Dr. Xue (Sherry) Gao, an associate professor at UPenn and leader of the study, in a press release. "These results show that many more medicines derived from natural products remain to be found." The findings were published in the journal Nature Chemical Biology. Aspergillus flavus is found in decaying leaves and compost, as well as on trees, plants and some crops, according to Mayo Clinic. While the fungus doesn't endanger most healthy people, it can cause respiratory issues for those who have weakened immune systems or are taking certain medications. Some of the more severe complications of the fungus can include bleeding in the lungs and life-threatening infections in the brain, heart and kidneys, Mayo Clinic stated. HISTORY OF THE ‘CURSE’ After archaeologists opened King Tut’s tomb in the 1920s, multiple members of the excavation team died suddenly, fueling rumors of a "curse" upon those who dared interfere with the pharaoh’s rest, according to the UPenn press release. Decades later, doctors hypothesized that fungal spores, which had been dormant for thousands of years, could have infected the team. In the 1970s, it happened again, the university stated. A dozen scientists entered another tomb, this time in Poland — and 10 died within a few weeks. Later investigations were said to reveal the presence of Aspergillus flavus in the tomb. CANCER-FIGHTING POTENTIAL Now, the same fungus linked to King Tut's tomb could have the capability to fight leukemia in a new form of cancer therapy. "There are a variety of compounds able to be produced by fungus," Gao told Fox News Digital. These compounds can be toxic to different cells, she noted, depending on the "biological management we are able to mitigate." The study aimed to find a specific kind of compound — ribosomally synthesized and post-translationally modified peptides, or "RiPPs" — within Aspergillus flavus, which was previously shown to be a good source. When this compound is able to enter cancer cells, Gao said, it may be able to stop their growth. "Cancer cells divide uncontrollably," Gao said in the release. "These compounds block the formation of microtubules, which are essential for cell division." |
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