Article

2020-07-16 -Signs, Portents, and the Weather-

Swiss stopped HCQ, deaths up; started HCQ again, deaths went down

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Posted by lord garth 2020-07-16 00:00|| || Front Page|| [10 views ] Top

#1 Graph copied from g(r)omgoru’s comment yesterday. Search and reapply works for some things I would otherwise not yet be able to do. :-)

Posted by trailing wife 2020-07-16 01:00|| 2020-07-16 01:00|| Front Page Top

#2 Garth, they stoped giving HCQ to new patients on may 27 to new patients.These already on HCQ kept getting it. And vice versa on Jun 11.

Posted by g(r)omgoru PB 2020-07-16 05:07|| 2020-07-16 05:07|| Front Page Top

#3 ^Damn touch screen!

Posted by g(r)omgoru 2020-07-16 06:26|| 2020-07-16 06:26|| Front Page Top

#4 "Experts" are those who know more and more about less and less till they know everything about nothing.

Scientists these days seem to be so intensely focused on their one miniscule area that they totally miss the bigger picture.

Not terribly helpful.

Posted by AlanC 2020-07-16 07:51|| 2020-07-16 07:51|| Front Page Top

#5 HCQ during pregnancy may prevent congenital heart block

Peter Izmirly, M.D., from the New York University School of Medicine in New York City, and colleagues recruited anti-SSA/Ro-positive mothers with a previous pregnancy complicated by CHB for a two-stage clinical trial (19 first stage and 35 second stage). Patients received 400 mg daily of hydroxychloroquine from before completion of gestational week 10 through pregnancy.

The researchers found that four of 54 pregnancies (7.4 percent) resulted in a primary outcome of second-degree or third-degree CHB any time during pregnancy in the intention-to-treat analysis. This was lower than the historical rate of recurrence of CHB of 18 percent. Nine mothers took potentially confounding medications after enrollment but before the primary outcome and were therefore replaced with nine additional mothers who were recruited and followed an identical protocol. In the per-protocol analysis, four of 54 fetuses (7.4 percent) developed a primary outcome. Secondary outcomes included one case of mild endocardial fibroelastosis and four cases of cutaneous neonatal lupus.

"Testing for anti-SSA/Ro antibodies is not part of the normal screening of pregnant women, but it should now be considered," a coauthor said in a statement. "One implication of our findings is that hydroxychloroquine could be effective in preventing CHB in newborns of first-time, pregnant women with anti-SSA/Ro antibodies, which could change the way we evaluate all pregnancies regardless of a mother's health."

Posted by Bright Pebbles 2020-07-16 07:52|| 2020-07-16 07:52|| Front Page Top

#6 I presume the Swiss have some people who know how to do a study.

Get primary data (not secondary and tertiary).

Get actual instructions on 'we stop HCQ' and 'we Start HCQ again' and get the dates on the original docs.

Get the hospital records and verify that HCQ was stopped and started on the dates.

Compare trends at different treatment centers and note any differences in outcomes.

Reanalyze.

Publish and get comments.

Posted by lord garth 2020-07-16 10:01|| 2020-07-16 10:01|| Front Page Top

#7 The study was French. The data was Swiss.

Posted by g(r)omgoru 2020-07-16 10:14|| 2020-07-16 10:14|| Front Page Top

#8 French used numbers from Johns Hopkins website.

Those numbers are at best secondary (probably tertiary) and, as we know, sometimes those numbers are modified, even weeks later, based on corrections.

Somebody needs to do the hard work of getting hospital and treatment center records and working from those.

Posted by lord garth 2020-07-16 11:35|| 2020-07-16 11:35|| Front Page Top

#9 Seriously, would anyone on this board prefer a ventilator over HCQ?

Posted by Iblis 2020-07-16 11:55|| 2020-07-16 11:55|| Front Page Top

23:48 Clem
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