Article

2020-12-14 Science & Technology

Ivermectin for COVID19: "If You Take It, You Will Not Get Sick"

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Posted by Deadeye Jaiting7534 2020-12-14 01:46|| || Front Page|| [12 views ] Top

#1 I still don't know, understand the chemical virus mechanics. We have been using ivermectin for 3 years for feral animal mite treatments. Typically only topical. Such doses are absorbed safely into the bloodstream in both humans and animals.

We store in the fridge. A 250 ml (8.5 fluid oz) bottles of Aspen Ivermax costs around $20. Topical doses depend on body weight. Some breeds will react badly with temporary nerve issues which manifest akin to stumbling coordination problems. Which dissipate over time.

Posted by Woodrow 2020-12-14 05:19|| 2020-12-14 05:19|| Front Page Top

#2 Ivermectin uses.

/\$20? Where's the profit in that (sarc).

Posted by JohnQC 2020-12-14 08:05|| 2020-12-14 08:05|| Front Page Top

#3 It's a de-worming agent for horses. One must be very careful to not self-medicate.

Posted by Deacon Blues 2020-12-14 08:14|| 2020-12-14 08:14|| Front Page Top

#4 COVID Critical Care Alliance has Ivermectin and OTC vitamins/supplements as outpatient treatment.

Wikipedia notes - As of 2019, ivermectin tablets in the United States were the least expensive treatment option for lice in children at about US$10 - and -

On 10 April 2020 the FDA issued guidance not to use ivermectin intended for animals as a treatment for Covid-19 in humans

Posted by Bobby 2020-12-14 08:50|| 2020-12-14 08:50|| Front Page Top

#5 Thanks, Bobby. Link saved for future reference.

Posted by trailing wife 2020-12-14 10:56|| 2020-12-14 10:56|| Front Page Top

#6 It's also used as a deworming med for humans.

Posted by Woodrow 2020-12-14 13:19|| 2020-12-14 13:19|| Front Page Top

#7 COVID-19
Numerous studies have been performed on the efficacy of ivermectin in controlling COVID-19,[13] and a protocol named IVERCOR-COVID19 was published in late November 2020 by doctors in Spain for globalized testing purposes.[14] On 10 April 2020 the FDA issued guidance not to use ivermectin intended for animals as a treatment for Covid-19 in humans.[15]

As one example, doctors in Bangladesh completed a randomized, double-blind, placebo-controlled trial pilot study of 72 patients. "A 5-day course of ivermectin was found to be safe and effective in treating mild COVID-19 adult patients... There were no severe adverse drug events recorded in the study." The authors remark that "The drugs are affordable (the full 5-day cost ranges from $.60-$1.8 USD for 5-day ivermectin) and readily available in Bangladesh thus are a highly attractive alternative for treating COVID-19 patients." The study would not have been possible without the contributions of the Governments of Bangladesh, Canada, Sweden and the UK.[7]

Posted by Woodrow 2020-12-14 13:32|| 2020-12-14 13:32|| Front Page Top

#8 Ivermectin was discovered in 1975 and came into medical use in 1981.[10][11] It is on the World Health Organization's List of Essential Medicines.[12] Ivermectin is an FDA-approved anti-parasitic agent.[7]

Pharmacodynamics
Ivermectin and other avermectins (insecticides most frequently used in home-use ant baits) are macrocyclic lactones derived from the bacterium Streptomyces avermitilis. Ivermectin kills by interfering with nervous system and muscle function, in particular by enhancing inhibitory neurotransmission.

The drug binds to glutamate-gated chloride channel receptors (GluClRs) in the membranes of invertebrate nerve and muscle cells, causing increased permeability to chloride ions, resulting in cellular hyper-polarization, followed by paralysis and death.[3][57] GluClRs are invertebrate-specific members of the Cys-loop family of ligand-gated ion channels present in neurons and myocytes.

Pharmacokinetics
Ivermectin can be given by mouth, topically, or via injection. It does not readily cross the blood–brain barrier of mammals due to the presence of P-glycoprotein,[58] (the MDR1 gene mutation affects function of this protein). Crossing may still become significant if ivermectin is given at high doses (in which case, brain levels peak 2–5 hours after administration). In contrast to mammals, ivermectin can cross the blood–brain barrier in tortoises, often with fatal consequences.

Ecotoxicity
Field studies have demonstrated the dung of animals treated with ivermectin supports a significantly reduced diversity of invertebrates, and the dung persists longer.[59]

History
The discovery of the avermectin family of compounds, from which ivermectin is chemically derived, was made by Satoshi Ōmura of Kitasato University, Tokyo and William C. Campbell of the Merck Institute for Therapeutic research. Ōmura identified avermectin from the bacterium Streptomyces avermitilis.[60] Campbell purified avermectin from cultures obtained from Ōmura and led efforts leading to the discovery of ivermectin, a derivative of greater potency and lower toxicity.[61] Ivermectin was introduced in 1981.[62] Half of the 2015 Nobel Prize in Physiology or Medicine was awarded jointly to Campbell and Ōmura for discovering avermectin, "the derivatives of which have radically lowered the incidence of river blindness and lymphatic filariasis, as well as showing efficacy against an expanding number of other parasitic diseases".[63]

Dogs with defects in the P-glycoprotein gene (MDR1), often collie-like herding dogs, can be severely poisoned by ivermectin. The mnemonic "white feet, don't treat" refers to Scotch collies that are vulnerable to ivermectin.[75] Some other dog breeds (especially the Rough Collie, the Smooth Collie, the Shetland Sheepdog, and the Australian Shepherd), also have a high incidence of mutation within the MDR1 gene (coding for P-glycoprotein) and are sensitive to the toxic effects of ivermectin.[76][77] Clinical evidence suggests kittens are susceptible to ivermectin toxicity.[78] A 0.01% ivermectin topical preparation for treating ear mites in cats is available.[79]

Posted by Woodrow 2020-12-14 13:33|| 2020-12-14 13:33|| Front Page Top

#9 WAPO is studiously ignoring this, NYT and othre lefty rags are calling it "bogus" without examining the documentation, equating it to HCQ. They stop short of cvalling Dr Kory and his colleagues as "quacks" because they dare to buck the system and expose the hypocrisy of Big Health establishment (Corporate Pharma, NIH, CDC, and fascist Fauci).

Watch and see that activity as proof of the deep state trying to supress the entire thing.

So the smears are already starting.

Posted by Deadeye Jaiting7534 2020-12-14 22:03|| 2020-12-14 22:03|| Front Page Top

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