Article

2020-04-10 -Signs, Portents, and the Weather-

Massive computer at Oak Ridge National Labs ID's 77 potential COVID-19 treatments

Archived material is restricted to Rantburg regulars and members. If you need access email fred.pruitt=at=gmail.com with your nick to be added to the members list. There is no charge to join Rantburg as a member.

Posted by Besoeker 2020-04-10 02:33|| || Front Page|| [5 views ] Top

#1 How successful was this supercomputer with SARS-CoV-1? MERS? Zika? Pick-a-Flu?

Posted by Clem 2020-04-10 05:25|| 2020-04-10 05:25|| Front Page Top

#2 Well I guess computers will never get this bug.

Posted by AlanC 2020-04-10 07:31|| 2020-04-10 07:31|| Front Page Top

#3 You may download the 314 MB report HERE and see where hydroxycloroquine ranks in their model.

Posted by Bobby 2020-04-10 07:45|| 2020-04-10 07:45|| Front Page Top

#4 n-silico Studies of Antimalarial-agent Artemisinin and Derivatives Portray More Potent Binding to Lys353 and Lys31-Binding Hotspots of SARS-CoV-2 Spike Protein than Hydroxychloroquine: Potential Repurposing of Artenimol for COVID-19.
Preprint submitted on 08.04.2020, 09:33 and posted on 09.04.2020, 06:15 by Moussa SEHAILIA Smain chemat
The role of hydroxychloroquine to prevent hACE2 from interacting with SARS-CoV-2 Spike protein is unveiled. Artemisinin & derived compounds entangle better than hydroxychloroquine into Lys353 and Lys31 binding hotspots of the virus Spike protein, therefore preventing infection occurs. Since these molecules are effective antivirals with excellent safety track records, their potential repurposing is recommended for clinical trials of COVID-19 patients.

Posted by crazyhorse 2020-04-10 08:04|| 2020-04-10 08:04|| Front Page Top

#5 Hydroxycloroquine is inexpensive, readily and widely available, India rather than China makes 70% of the world supply, according to Dron66046, and was the first off the blocks to show a positive impact on patients. You ~~go to war~~ fight the pandemic with the tools you have at hand, then upgrade as there is time and money to do so. Which is why FDA and CDC footdragging is so dangerous; they know that a raging pandemic is when early actions make a huge difference, but demanded it only of the populace, not themselves.

Also, models. The scientists now have seven things to test, and then later another seventy. How the suggestions work in the real world will show how well the scientists and programmers currently understand the disease they were trying to model.

Posted by trailing wife 2020-04-10 11:00|| 2020-04-10 11:00|| Front Page Top

#6 Artemisinin?
Can it be combined for greater efficacy with D'Artagnanin, Athosin and Porthosin?

Posted by Lex 2020-04-10 11:28|| 2020-04-10 11:28|| Front Page Top

#7 ^Comes from "Artemis", not "Aramis".

Posted by g(r)omgoru 2020-04-10 11:33|| 2020-04-10 11:33|| Front Page Top

#8 You can get Artemisinin at health food stores and online from Homeopathy sites, so it's not really regulated (or required to be).

This, of course, won't stand well with the FDA (or their Big Pharma/$$$ cohorts) and expect some BS language coming from them shortly.

Posted by Mullah Richard 2020-04-10 12:05|| 2020-04-10 12:05|| Front Page Top

#9 Artemisinin is the oldest known anti-flu and malarial preventive. Not a drug really, it's derivatives and compounds are used as supplements in the modern form of Traditional Chinese Medicine.

Discovered by the Yellow Emperor, I think. It's called 'sweet wormwood' and can possibly prevent malaria if taken before entering an infected environment. Maybe some derivative can cure too, I don't know.

When they say it's safer, I think they mean it's already taken as supplements in China and is organically derived ?

Posted by Dron66046 2020-04-10 19:08|| 2020-04-10 19:08|| Front Page Top

#10 Huh. I use it.

Posted by Whiskey Mike 2020-04-10 22:55|| 2020-04-10 22:55|| Front Page Top

23:25 Skidmark
23:10 Whiskey Mike
22:58 Whiskey Mike
22:56 Whiskey Mike
22:55 Whiskey Mike
22:50 Whiskey Mike
21:57 Bangkok Billy
21:41 SteveS
21:34 magpie
21:15 Clem
21:13 Jack Salami
20:42 no mo uro
20:37 Procopius2k
20:34 no mo uro
20:30 no mo uro
20:14 magpie
20:14 Clem
20:03 DooDahMan
20:02 DooDahMan
19:53 swksvolFF
19:37 Texhooey
19:36 Dron66046
19:27 M. Murcek
19:23 SteveS